Drug Information

Drug General Information
Drug ID
DXQ9OS
Drug Name
(Z)-N-[2-Oxo-3-({4-oxo-3-[3-oxo-3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-5-yl]benzenesulfonamide
Synonyms
CHEMBL1215280
Indication Discovery agent Investigative [1587926]
Formula
C30H30N4O5S
Canonical SMILES
O=C(CCc1c(\\C=C\\2/C(=O)Nc3ccc(NS(=O)(=O)c4ccccc4)cc23)[nH]c5CCCC(=O)c15)N6CCCC6
InChI
InChI=1S/C30H30N4O5S/c35-27-10-6-9-25-29(27)21(12-14-28(36)34-15-4-5-16-34)26(31-25)18-23-22-17-19(11-13-24(22)32-30(23)37)33-40(38,39)20-7-2-1-3-8-20/h1-3,7-8,11,13,17-18,31,33H,4-6,9-10,12,14-16H2,(H,32,37)/b23-18-
InChIKey
JVXJMEFHHQBIIG-NKFKGCMQSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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