Drug Information

Drug General Information
Drug ID
DXG1EN
Drug Name
(Z)-Ethyl 3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate
Synonyms
CHEMBL1215218
Indication Discovery agent Investigative [1587926]
Formula
C28H27N3O6S
Canonical SMILES
CCOC(=O)CCc1c(\\C=C\\2/C(=O)Nc3ccc(NS(=O)(=O)c4ccccc4)cc23)[nH]c5CCCC(=O)c15
InChI
InChI=1S/C28H27N3O6S/c1-2-37-26(33)14-12-19-24(29-23-9-6-10-25(32)27(19)23)16-21-20-15-17(11-13-22(20)30-28(21)34)31-38(35,36)18-7-4-3-5-8-18/h3-5,7-8,11,13,15-16,29,31H,2,6,9-10,12,14H2,1H3,(H,30,34)/b21-16-
InChIKey
BBTDOQATPTVBOJ-PGMHBOJBSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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