Drug Information

Drug General Information
Drug ID
DX1UHS
Drug Name
(R)-3-(4-Phenethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid
Synonyms
CHEMBL425702
Indication Discovery agent Investigative [1587926]
Formula
C25H24O4S
Canonical SMILES
OC(=O)[C@H]1Cc2ccccc2CC1S(=O)(=O)c3ccc(CCc4ccccc4)cc3
InChI
InChI=1S/C25H24O4S/c26-25(27)23-16-20-8-4-5-9-21(20)17-24(23)30(28,29)22-14-12-19(13-15-22)11-10-18-6-2-1-3-7-18/h1-9,12-15,23-24H,10-11,16-17H2,(H,26,27)/t23-,24?/m0/s1
InChIKey
SCMUFXMYUJBJMV-UXMRNZNESA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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