Drug Information

Drug General Information
Drug ID
DX2NIJ
Drug Name
(R)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-N-phenylpiperidine-3-carboxamide
Synonyms
CHEMBL1765733
Indication Discovery agent Investigative [1587926]
Formula
C23H24N8O
Canonical SMILES
Nc1nc(cc(n1)c2ccc3c(N)n[nH]c3c2)N4CCC[C@H](C4)C(=O)Nc5ccccc5
InChI
InChI=1S/C23H24N8O/c24-21-17-9-8-14(11-19(17)29-30-21)18-12-20(28-23(25)27-18)31-10-4-5-15(13-31)22(32)26-16-6-2-1-3-7-16/h1-3,6-9,11-12,15H,4-5,10,13H2,(H,26,32)(H3,24,29,30)(H2,25,27,28)/t15-/m1/s1
InChIKey
CQRFXINTEFATOH-OAHLLOKOSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.