| Drug General Information |
| Drug ID |
DXS5LY
|
| Drug Name |
(E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-p-tolylacrylate
|
| Synonyms |
CHEMBL1173653
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C16H17N3O4
|
| Canonical SMILES |
Cc1ccc(\\C=C\\C(=O)OCCn2c(C)ncc2[N+](=O)[O-])cc1
|
| InChI |
InChI=1S/C16H17N3O4/c1-12-3-5-14(6-4-12)7-8-16(20)23-10-9-18-13(2)17-11-15(18)19(21)22/h3-8,11H,9-10H2,1-2H3/b8-7+
|
| InChIKey |
IJUNVQOREZBHKC-BQYQJAHWSA-N
|
| Target and Pathway |
| Target(s) |
Epidermal growth factor receptor III |
Target Info |
|
[1]
|
|---|
| Receptor protein-tyrosine kinase erbB-2 |
Target Info |
|
[1]
|
|
KEGG Pathway
|
ErbB signaling pathway
|
|
Calcium signaling pathway
|
|
HIF-1 signaling pathway
|
|
Focal adhesion
|
|
Adherens junction
|
|
Pathways in cancer
|
|
Proteoglycans in cancer
|
|
MicroRNAs in cancer
|
|
Pancreatic cancer
|
|
Endometrial cancer
|
|
Prostate cancer
|
|
Bladder cancer
|
|
Non-small cell lung cancer
|
|
Central carbon metabolism in cancer
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Cadherin signaling pathway
|
|
EGF receptor signaling pathway
|
|
Pathway Interaction Database
|
ErbB4 signaling events
|
|
ErbB2/ErbB3 signaling events
|
|
ErbB receptor signaling network
|
|
a6b1 and a6b4 Integrin signaling
|
|
Validated targets of C-MYC transcriptional repression
|
|
PathWhiz Pathway
|
Phosphatidylinositol Phosphate Metabolism
|
|
Reactome
|
SHC1 events in ERBB2 signaling
|
|
PLCG1 events in ERBB2 signaling
|
|
PIP3 activates AKT signaling
|
|
GRB2 events in ERBB2 signaling
|
|
PI3K events in ERBB2 signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
Sema4D induced cell migration and growth-cone collapse
|
|
RAF/MAP kinase cascade
|
|
WikiPathways
|
DNA Damage Response (only ATM dependent)
|
|
ErbB Signaling Pathway
|
|
EGF/EGFR Signaling Pathway
|
|
Focal Adhesion
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Bladder Cancer
|
|
Signaling by ERBB2
|
|
Integrated Pancreatic Cancer Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Leptin signaling pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
Semaphorin interactions
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
