Drug Information
| Drug General Information | |||||
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| Drug ID |
DXW7H8
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| Drug Name |
(3R,5S)-5-((4-(1-(3-fluorophenylsulfonyl)-1H-indazol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL451074
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C30H26FN7O5S2
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| Canonical SMILES |
Fc1cccc(c1)S(=O)(=O)n2ncc3cc(Nc4ncnc5cc(C#C[C@@H]6C[C@H](CN6)OC(=O)N7CCOCC7)sc45)ccc23
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| InChI |
InChI=1S/C30H26FN7O5S2/c31-20-2-1-3-25(13-20)45(40,41)38-27-7-5-22(12-19(27)16-35-38)36-29-28-26(33-18-34-29)15-24(44-28)6-4-21-14-23(17-32-21)43-30(39)37-8-10-42-11-9-37/h1-3,5,7,12-13,15-16,18,21,23,32H,8-11,14,17H2,(H,33,34,36)/t21-,23-/m1/s1
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| InChIKey |
DNGKMKTZKCGWMO-FYYLOGMGSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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