Drug Information

Drug General Information
Drug ID
DXM5LG
Drug Name
(2S,5R)-4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide
Synonyms
CHEMBL1765741
Indication Discovery agent Investigative [1587926]
Formula
C23H24N8O2
Canonical SMILES
C[C@@H]1CO[C@@H](CN1c2cc(nc(N)n2)c3ccc4c(N)n[nH]c4c3)C(=O)Nc5ccccc5
InChI
InChI=1S/C23H24N8O2/c1-13-12-33-19(22(32)26-15-5-3-2-4-6-15)11-31(13)20-10-17(27-23(25)28-20)14-7-8-16-18(9-14)29-30-21(16)24/h2-10,13,19H,11-12H2,1H3,(H,26,32)(H3,24,29,30)(H2,25,27,28)/t13-,19+/m1/s1
InChIKey
JTGMDPHLGBACAV-YJYMSZOUSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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