Drug Information
| Drug General Information | |||||
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| Drug ID |
DXI0MG
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| Drug Name |
(2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(pyridin-2-ylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide
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| Synonyms |
CHEMBL398154
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C28H28N6O5
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OCc4ccccn4)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C28H28N6O5/c1-4-38-25-14-20-19(12-22(25)32-27(37)9-7-11-34(2)3)28(31-17-30-20)33-21-13-24(36)26(15-23(21)35)39-16-18-8-5-6-10-29-18/h5-10,12-15,17H,4,11,16H2,1-3H3,(H,32,37)(H,30,31,33)/b9-7+
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| InChIKey |
QVVKYQOIYUSEGU-VQHVLOKHSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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