Drug Information
| Drug General Information | |||||
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| Drug ID |
DX7GJY
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| Drug Name |
(2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(2-thienylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide
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| Synonyms |
CHEMBL243839
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C27H27N5O5S
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OCc4cccs4)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C27H27N5O5S/c1-4-36-24-13-19-18(11-21(24)30-26(35)8-5-9-32(2)3)27(29-16-28-19)31-20-12-23(34)25(14-22(20)33)37-15-17-7-6-10-38-17/h5-8,10-14,16H,4,9,15H2,1-3H3,(H,30,35)(H,28,29,31)/b8-5+
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| InChIKey |
NZFPJFMKRLAGLA-VMPITWQZSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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