Drug Information

Drug General Information
Drug ID
DX2PSK
Drug Name
CHEMBL1076330
Indication Discovery agent Investigative [1587926]
Formula
C15H12N6S
Canonical SMILES
Cn1cnc(c2ccccc2)c1c3nc4c(N)ncnc4s3
InChI
InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18)
InChIKey
LRVWWMYFXPCSOS-UHFFFAOYSA-N
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 1 Target Info [1587926]
Angiopoietin 1 receptor Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
Rheumatoid arthritis
NetPath Pathway Wnt Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2angiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
SHP2 signaling
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Focal Adhesion
Signaling by VEGF
AngiogenesisWP363:Wnt Signaling Pathway Netpath
Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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