Target Information

Target General Infomation
Target ID
T77009
Former ID
TTDI00956
Target Name
Thioredoxin reductase
Gene Name
PRDX5
Synonyms
AOEB166; Alu corepressor 1; Antioxidant enzyme B166; Liver tissue 2Dpage spot 71B; PLP; Peroxiredoxin V; Peroxiredoxin5, mitochondrial; Peroxisomal antioxidant enzyme; PrxV; TPx type VI; Thioredoxin peroxidase PMP20; PRDX5
Target Type
Successful
Disease Brain cancer [ICD9: 191, 225.0; ICD10: C71, D33]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10: B20-B26]
Function
Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
BioChemical Class
Peroxidases
UniProt ID
P30044
EC Number
EC 1.11.1.15
Sequence
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGD
AIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGV
QVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKR
FSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL
Drugs and Mode of Action
Drug(s) Motexafin gadolinium Drug Info Approved Brain cancer [535596]
Motexafin gadolinium Drug Info Phase 3 Human immunodeficiency virus infection [537003]
Modulator Motexafin gadolinium Drug Info [537003]
References
Ref 535596Photodynamic therapy: applications in atherosclerotic vascular disease with motexafin lutetium. Catheter Cardiovasc Interv. 2002 Nov;57(3):387-94.
Ref 537003Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9. Epub 2009 Jan 1.
Ref 537003Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9. Epub 2009 Jan 1.

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