Target Information

Target General Infomation
Target ID
T35040
Former ID
TTDNR00648
Target Name
Basigin
Gene Name
BSG
Synonyms
5F7; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; OK blood group antigen; TCSF; Tumor cell-derived collagenase stimulatory factor; BSG
Target Type
Clinical Trial
Disease Graft-versus-host disease [ICD9: 279.5; ICD10: T86.0]
Liver cancer [ICD9: 140-229, 155, 203.0; ICD10: C22]
Function
Plays an important role intargeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
BioChemical Class
Basigin family
UniProt ID
P35613
Sequence
MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEG
QGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT
RAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKE
DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAML
VCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYR
CNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDA
GSAPLKSSGQHQNDKGKNVRQRNSS
Drugs and Mode of Action
Drug(s) Gavilimomab Drug Info Phase 2/3 Graft-versus-host disease [521512]
[131I]-Metuximab injection Drug Info Phase 2 Liver cancer [522539]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
Pathway Interaction Database Syndecan-1-mediated signaling events
Reactome Degradation of the extracellular matrix
Basigin interactions
Integrin cell surface interactions
Pyruvate metabolism
WikiPathways The citric acid (TCA) cycle and respiratory electron transport
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Matrix Metalloproteinases
References
Ref 521512ClinicalTrials.gov (NCT00035880) Study Comparing ABX-CBL (Monoclonal Antibody) Versus Atgam in Patients With Steroid Resistant Acute Graft Versus Host Disease. U.S. National Institutes of Health.
Ref 522539ClinicalTrials.gov (NCT00819650) A Trial of Licartin for Preventing Tumor Recurrence After Liver Resection. U.S. National Institutes of Health.
Ref 528202Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):435-44.
Ref 550396National Cancer Institute Drug Dictionary (drug id 38221).

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