Target Information

Target General Infomation
Target ID
T13127
Target Name
Farnesyl protein transferase
Target Type
Clinical Trial
Disease Lymphoma [ICD9: 202.8, 208.9; ICD10: C81-C86]
Non-small cell lung cancer [ICD10: C33-C34]
Pancreatic cancer; Colorectal cancer [ICD9: 140-229, 153, 154, 157; ICD10: C18-C21, C25]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
BioChemical Class
Transferases (EC:2)
UniProt ID
P49354||P49356
EC Number
EC 2.5.1.58
Drugs and Mode of Action
Drug(s) Zarnestra Drug Info Phase 1/2 Pancreatic cancer; Colorectal cancer [537114]
BMS214662 Drug Info Phase 1 Non-small cell lung cancer [521478], [521493], [542930]
GGTI-2418 Drug Info Phase 1 Solid tumours [548904]
L-778123 Drug Info Phase 1 Lymphoma [521452], [527183]
Lonafarnib Drug Info Discontinued in Phase 3 Non-small cell lung cancer [537114], [542928]
Modulator BMS214662 Drug Info
GGTI-2418 Drug Info
L-778123 Drug Info
Lonafarnib Drug Info
Zarnestra Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 521452ClinicalTrials.gov (NCT00003430) L-778,123 in Treating Patients With Recurrent or Refractory Solid Tumors. U.S. National Institutes of Health.
Ref 521478ClinicalTrials.gov (NCT00006242) BMS-214662 in Treating Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 521493ClinicalTrials.gov (NCT00022529) BMS-214662 Plus Trastuzumab in Treating Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 527183A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Clin Cancer Res. 2004 Aug 15;10(16):5447-54.
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
Ref 542928(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8024).
Ref 542930(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8026).
Ref 548904Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030147)

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