Target General Infomation
Target ID
T67730
Former ID
TTDR00170
Target Name
Putative tryptase delta
Gene Name
TPSD1
Synonyms
Delta tryptase; HmMCP-3-like tryptase III; Mast cell mMCP-7-like; TPSD1
Target Type
Research
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
BioChemical Class
Peptidase
Target Validation
T67730
UniProt ID
EC Number
EC 3.4.21.59
Sequence
MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGP
YWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQF
YIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPY
PLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVN
GT
Inhibitor BMS-262084 Drug Info [526439]
References
Ref 526439Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33.Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

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