Target Information

Target General Infomation
Target ID
T26073
Former ID
TTDI02515
Target Name
G protein coupled receptor 87
Gene Name
GPR87
Synonyms
Gprotein coupled receptor 87; Gprotein coupled receptor 95; GPR87
Target Type
Research
Function
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
BioChemical Class
GPCR rhodopsin
UniProt ID
Q9BY21
Sequence
MGFNLTLAKLPNNELHGQESHNSGNRSDGPGKNTTLHNEFDTIVLPVLYLIIFVASILLN
GLAVWIFFHIRNKTSFIFYLKNIVVADLIMTLTFPFRIVHDAGFGPWYFKFILCRYTSVL
FYANMYTSIVFLGLISIDRYLKVVKPFGDSRMYSITFTKVLSVCVWVIMAVLSLPNIILT
NGQPTEDNIHDCSKLKSPLGVKWHTAVTYVNSCLFVAVLVILIGCYIAISRYIHKSSRQF
ISQSSRKRKHNQSIRVVVAVFFTCFLPYHLCRIPFTFSHLDRLLDESAQKILYYCKEITL
FLSACNVCLDPIIYFFMCRSFSRRLFKKSNIRTRSESIRSLQSVRRSEVRIYYDYTDV
Antagonist dioctanoylglycerol pyrophosphate Drug Info [529073]
Ki16425 Drug Info [529073]
Agonist LPA Drug Info [529462]
Pathways
WikiPathways GPCRs, Class A Rhodopsin-like
References
Ref 529073The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. Epub 2007 Sep 24.
Ref 529462Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12.

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