Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T77139
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| Former ID |
TTDR01005
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| Target Name |
Mitogen-activated protein kinasekinase kinase 3
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| Gene Name |
MAP3K3
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| Synonyms |
MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3; MEKK3; MAP3K3
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| Target Type |
Research
|
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| Function |
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
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| BioChemical Class |
Kinase
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| UniProt ID | |||||
| EC Number |
EC 2.7.11.25
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| Sequence |
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL RRIFVEARQRPSAEELLTHHFAQLMY |
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| Pathways | |||||
| NetPath Pathway | TSH Signaling Pathway | ||||
| PANTHER Pathway | B cell activation | ||||
| EGF receptor signaling pathway | |||||
| FGF signaling pathway | |||||
| Pathway Interaction Database | p38 MAPK signaling pathway | ||||
| Regulation of p38-alpha and p38-beta | |||||
| IL1-mediated signaling events | |||||
| TNF receptor signaling pathway | |||||
| Reactome | Interleukin-1 signaling | ||||
| WikiPathways | Insulin Signaling | ||||
| EGF/EGFR Signaling Pathway | |||||
| MAPK Cascade | |||||
| Structural Pathway of Interleukin 1 (IL-1) | |||||
| EBV LMP1 signaling | |||||
| TNF alpha Signaling Pathway | |||||
| IL-1 signaling pathway | |||||
| Interleukin-1 signaling | |||||
| References | |||||
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