Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T68253
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| Former ID |
TTDR00165
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| Target Name |
D-alanine--D-alanine ligase
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| Gene Name |
ddl
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| Synonyms |
D-Ala-D-Ala ligase; D-alanine:D-alanine ligase; D-alanylalanine synthetase; ddl
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| Target Type |
Research
|
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| Disease | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99] | ||||
| Function |
Cell wall formation (by similarity).
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| BioChemical Class |
Carbon-nitrogen ligase
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| UniProt ID | |||||
| EC Number |
EC 6.3.2.4
|
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| Sequence |
MSANDRRDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAVGITPAGSWVLTD
ANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFPVLHGP YGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLH RQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELEC GVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAAELDVPAKVDDQVAEAIRQ LAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPGFTTISMYPRMWAASGVDYPTLLAT MIETALARGVGLH |
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| Inhibitor | Adenosine-5'-Diphosphate | Drug Info | [551391] | ||
| Binder | Glycopeptides | Drug Info | [538034] | ||
| Pathways | |||||
| KEGG Pathway | D-Alanine metabolism | ||||
| Peptidoglycan biosynthesis | |||||
| Metabolic pathways | |||||
| Vancomycin resistance | |||||
| References | |||||
| Ref 538034 | D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6480-3. | ||||
| Ref 551391 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
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