Target Information

Target General Infomation
Target ID
T52969
Former ID
TTDR00281
Target Name
CAP-dependent endonuclease
Target Type
Discontinued
Drugs and Mode of Action
Drug(s) Flutimide Drug Info Terminated Discovery agent [546072]
Inhibitor 4-substituted 2,4-dioxobutanoic acids Drug Info [537973]
Flutimide Drug Info [535228]
References
Ref 546072Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006184)
Ref 535228Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16.
Ref 537973Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrob Agents Chemother. 1996 May;40(5):1304-7.

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