Target Information

Target General Infomation
Target ID
T23547
Former ID
TTDS00125
Target Name
Opioid receptor
Target Type
Successful
Disease Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Alcohol dependence [ICD10: F10]
Analgesia [ICD9: 338; ICD10: R52, G89]
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Cancer pain [ICD9: 140-229, 338,780; ICD10: R52, G89]
Constipation [ICD9: 564; ICD10: K59.0]
Dry cough; Drug withdrawal syndrome; Ppioid type drug dependence [ICD10: R05]
Hepatitis virus infection [ICD9: 573.3; ICD10: K75.9]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10: B20-B26]
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25]
Influenza A infection [ICD10: J10, J11]
Moderate to severe pain [ICD10: R52, G89]
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Opioid induced adverse effect [ICD9: 304; ICD10: F11]
Obesity [ICD9: 278; ICD10: E66]
Opioid addication [ICD10: F11]
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
Parkinson's disease [ICD9: 332; ICD10: G20]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
BioChemical Class
GPCR rhodopsin
Target Validation
T23547
Drugs and Mode of Action
Drug(s) Dextropropoxyphene Drug Info Approved Pain [536942], [542582]
Ketobemidone Drug Info Approved Pain [551871]
Levorphanol Drug Info Approved Moderate to severe pain [551871]
Methadone Drug Info Approved Dry cough; Drug withdrawal syndrome; Ppioid type drug dependence [551871]
Nalmefene Drug Info Approved Opioid addication [551871]
Naltrexone Drug Info Approved Alcohol dependence [551871]
Oxymorphone Drug Info Approved Moderate to severe pain [551871]
Pentazocine Drug Info Approved Moderate to severe pain [551871]
Sufentanil Drug Info Approved Analgesia [551871]
Tilidine Drug Info Approved Pain [551871]
Dihydrocodeine Drug Info Phase 4 Cancer pain [522148], [542583]
Naltrexone Drug Info Phase 4 Human immunodeficiency virus infection [525241], [539012]
Oxymorphone Drug Info Phase 4 Pain [522753], [542100]
ALO-02 Oxycodone- naltrexone core Drug Info Phase 3 Pain [551491]
Bupropion+naltrexone Drug Info Phase 3 Obesity [532233]
Oravescent fentanyl Drug Info Phase 3 Neuropathic pain [536374]
AeroLEF Drug Info Phase 2 Pain [522487]
AZD-7268 Drug Info Phase 2 Anxiety disorder [522867], [542769]
CNSB-001 Drug Info Phase 2 Neuropathic pain [548808]
JKB-122 Drug Info Phase 2 Hepatitis virus infection [525323]
NP-2 Drug Info Phase 2 Influenza A infection [548787]
OCFENTANIL Drug Info Phase 2 Pain [531161]
Odelepran Drug Info Phase 2 Alcohol use disorders [522511]
Oxytrex Drug Info Phase 2 Pain [522403]
S-297995 Drug Info Phase 2 Opioid induced adverse effect [551683]
PTI-202 Drug Info Phase 1 Pain [548354]
SYN-1001 Drug Info Phase 1 Pain [547773]
CB-01-16 Drug Info Preclinical Constipation [548954]
Propiram fumarate Drug Info Discontinued in Phase 3 Cancer pain [545491]
CereCRIB Drug Info Discontinued in Phase 2 Pain [546394]
OxycoDex Drug Info Discontinued in Phase 2 Pain [547593]
PTI-701 Drug Info Discontinued in Phase 2 Pain [547276]
Ultramorph Drug Info Discontinued in Phase 2 Pain [547177]
BL-1827 Drug Info Discontinued in Phase 1 Cancer pain [547169]
APF-580 Drug Info Terminated Pain [548583]
EK-399 Drug Info Terminated Inflammatory disease [545666]
Org-30035 Drug Info Terminated Psychotic disorders [545339]
OX-23 Drug Info Terminated Pain [548624]
Agonist AeroLEF Drug Info [544239]
BL-1827 Drug Info [547170]
CNSB-001 Drug Info [544320]
Dextropropoxyphene Drug Info [536942]
Levorphanol Drug Info [535895]
Methadone Drug Info [537460], [537485]
Oravescent fentanyl Drug Info [536374]
SYN-1001 Drug Info [527377]
Ultramorph Drug Info [525691]
Modulator ALO-02 Oxycodone- naltrexone core Drug Info [527586]
APF-580 Drug Info [550145]
AZD-7268 Drug Info [550881]
BRIFENTANIL Drug Info [531532], [551871]
CereCRIB Drug Info [550829]
Dihydrocodeine Drug Info [526452]
EK-399 Drug Info [528069]
JKB-122 Drug Info [550158], [551871]
Ketobemidone Drug Info [534254], [551871]
OCFENTANIL Drug Info [530205], [551871]
Org-30035 Drug Info [550146]
OxycoDex Drug Info [531999]
Oxymorphone Drug Info [542100]
Oxytrex Drug Info [528981]
Propiram fumarate Drug Info [533551]
PTI-202 Drug Info [551481]
PTI-701 Drug Info [551480]
Tilidine Drug Info [527358], [551871]
Antagonist Bupropion+naltrexone Drug Info [536710]
CB-01-16 Drug Info [550566]
Cyprodine Drug Info [536285]
Nalmefene Drug Info [536742], [536928]
Naltrexone Drug Info [529288], [551871]
NP-2 Drug Info [526015]
Odelepran Drug Info [532470]
Pentazocine Drug Info [534923], [537855]
S-297995 Drug Info [551683]
Sufentanil Drug Info [537460]
References
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Ref 526015Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes. J Biol Chem. 2001 Jun 1;276(22):18688-94. Epub 2001 Mar 14.
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Ref 527358Actions of tilidine and nortilidine on cloned opioid receptors. Eur J Pharmacol. 2005 Jan 4;506(3):205-8. Epub 2004 Dec 15.
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