Target Information

Target General Infomation
Target ID
T82499
Former ID
TTDS00201
Target Name
CAMP-phosphodiesterase
Synonyms
3',5'-cyclic-nucleotide phosphodiesterase; Cyclic Amp phosphodiesterase
Target Type
Discontinued
Disease Asthma [ICD10: J45]
BioChemical Class
Phosphoric diester hydrolases
Target Validation
T82499
EC Number
EC 3.1.4.17
Drugs and Mode of Action
Drug(s) Ro 20-1724 Drug Info Terminated Asthma [540721], [545620]
Inhibitor Iso-caffeine Drug Info [537894]
Ro 20-1724 Drug Info [537933]
S-(-)-enantiomer of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) Drug Info [537894]
Trifluperidol Drug Info [537894]
References
Ref 540721(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5258).
Ref 545620Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003923)
Ref 537894Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94.
Ref 537933Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol. 1993 May;100(5):681-4.

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