Target Information

Target General Infomation
Target ID
T36806
Former ID
TTDR00732
Target Name
Arginase II, mitochondrial
Gene Name
ARG2
Synonyms
Arginase II; Human penile arginase; Kidney-type arginase; Non-hepatic arginase; ARG2
Target Type
Clinical Trial
Disease Trypanosoma brucei gambiense infection [ICD9: 86.5; ICD10: B56]
Function
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
P78540
EC Number
EC 3.5.3.1
Sequence
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
Drugs and Mode of Action
Drug(s) Difluoromethylornithine Drug Info Phase 2 Trypanosoma brucei gambiense infection [523970]
Inhibitor Difluoromethylornithine Drug Info [535841]
N-hydroxy-nor-L-arginine Drug Info [535841]
S-(2-boronoethyl)-L-cysteine Drug Info [535130]
S-2-(Boronoethyl)-L-Cysteine Drug Info [551393]
Pathways
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Biosynthesis of antibiotics
Biosynthesis of amino acids
Amoebiasis
NetPath Pathway TCR Signaling Pathway
WikiPathways Urea cycle and metabolism of amino groups
Metabolism of amino acids and derivatives
References
Ref 523970ClinicalTrials.gov (NCT01636128) Urinary Biomarker Study With Sulindac and Difluoromethylornithine. U.S. National Institutes of Health.
Ref 535130Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88.
Ref 535841Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 2003 Oct 21;108(16):2000-6. Epub 2003 Sep 29.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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