Target Information

Target General Infomation
Target ID
T84560
Former ID
TTDR00083
Target Name
Mitochondrial uncoupling protein 2
Gene Name
UCP2
Synonyms
UCP 2; UCPH; UCP2
Target Type
Clinical Trial
Disease Obesity [ICD9: 278; ICD10: E66]
Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
BioChemical Class
Mitochondrial carrier
UniProt ID
P55851
Sequence
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR
GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL
LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS
PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT
RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA
ACTSREAPF
Drugs and Mode of Action
Drug(s) CL-316,243 Drug Info Phase 2 Obesity [533802], [540400]
Stimulator Beta 3-adrenoceptor Drug Info [534866]
Inducer CL-316,243 Drug Info [538030]
NC-2100 Drug Info [535014]
Pathways
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
WikiPathways Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Electron Transport Chain
References
Ref 533802Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82.
Ref 540400(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3462).
Ref 534866Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes--an update. Diabetes Metab. 1999 Mar;25(1):11-21.
Ref 535014A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67.
Ref 538030Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37.

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