Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T55293
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| Former ID |
TTDR00276
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| Target Name |
Integrin alpha-2
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| Gene Name |
ITGA2
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| Synonyms |
Adhesive platelet receptor alpha1 beta2; Alpha 2 beta 1 integrin; CD49b; Collagen receptor; GPIa; GPIa/IIa; Glycoprotein Ia-IIa; Integrin alpha(2)beta(1); Integrin alpha2beta 1; Platelet glycoprotein Ia/IIa; Platelet membrane glycoprotein Ia; VLA-2; VLA-2 alphachain; ITGA2
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| Target Type |
Clinical Trial
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| Disease | Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | ||||
| Function |
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
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| BioChemical Class |
Integrin
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| Target Validation |
T55293
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| UniProt ID | |||||
| Sequence |
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKG
NWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILT RNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCD ESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATS QTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCN HDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQ IFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFP KQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQ AHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKKGILGQH QFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKY SQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEAS FTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKEN NERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKV FSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTG IVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQ NLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSI VHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCN ADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIW NGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSII AGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS |
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| Drugs and Mode of Action | |||||
| Pathways | |||||
| KEGG Pathway | Phagosome | ||||
| PI3K-Akt signaling pathway | |||||
| Focal adhesion | |||||
| ECM-receptor interaction | |||||
| Platelet activation | |||||
| Hematopoietic cell lineage | |||||
| Regulation of actin cytoskeleton | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Small cell lung cancer | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |||||
| Dilated cardiomyopathy | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| PANTHER Pathway | Integrin signalling pathway | ||||
| Pathway Interaction Database | Beta1 integrin cell surface interactions | ||||
| Integrin family cell surface interactions | |||||
| Arf6 trafficking events | |||||
| CXCR4-mediated signaling events | |||||
| Plexin-D1 Signaling | |||||
| Syndecan-2-mediated signaling events | |||||
| VEGFR3 signaling in lymphatic endothelium | |||||
| Reactome | Integrin cell surface interactions | ||||
| Laminin interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| CHL1 interactions | |||||
| Platelet Adhesion to exposed collagen | |||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Focal Adhesion | |||||
| Human Complement System | |||||
| Extracellular matrix organization | |||||
| Interleukin-11 Signaling Pathway | |||||
| Arrhythmogenic Right Ventricular Cardiomyopathy | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| Platelet Adhesion to exposed collagen | |||||
| Integrin-mediated Cell Adhesion | |||||
| L1CAM interactions | |||||
| Integrin cell surface interactions | |||||
| References | |||||
| Ref 528383 | Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. Epub 2006 Aug 21.Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. | ||||
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