Target Information
Target General Infomation | |||||
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Target ID |
T88430
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Former ID |
TTDR01370
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Target Name |
mRNA of A-Raf
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Gene Name |
ARAF
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Synonyms |
Proto-oncogene A-Raf (mRNA); Proto-oncogene A-Raf-1 (mRNA); Proto-oncogene Pks (mRNA); Serine/threonine-protein kinase A-Raf (mRNA); ARAF
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Target Type |
Clinical Trial
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Disease | Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | ||||
Function |
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.11.1
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Sequence |
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS AARLVP |
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Drugs and Mode of Action | |||||
Pathways | |||||
KEGG Pathway | ErbB signaling pathway | ||||
FoxO signaling pathway | |||||
Vascular smooth muscle contraction | |||||
Natural killer cell mediated cytotoxicity | |||||
Long-term potentiation | |||||
Serotonergic synapse | |||||
Long-term depression | |||||
Regulation of actin cytoskeleton | |||||
Insulin signaling pathway | |||||
Progesterone-mediated oocyte maturation | |||||
Alcoholism | |||||
Hepatitis C | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
Colorectal cancer | |||||
Renal cell carcinoma | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Glioma | |||||
Prostate cancer | |||||
Melanoma | |||||
Bladder cancer | |||||
Chronic myeloid leukemia | |||||
Acute myeloid leukemia | |||||
Non-small cell lung cancer | |||||
PANTHER Pathway | Angiogenesis | ||||
B cell activation | |||||
Integrin signalling pathway | |||||
Interleukin signaling pathway | |||||
PDGF signaling pathway | |||||
T cell activation | |||||
VEGF signaling pathway | |||||
Ras Pathway | |||||
CCKR signaling map ST | |||||
Reactome | RAF activation | ||||
MAP2K and MAPK activation | |||||
Negative regulation of MAPK pathway | |||||
WikiPathways | ErbB Signaling Pathway | ||||
MAPK Cascade | |||||
Signaling Pathways in Glioblastoma | |||||
Integrated Breast Cancer Pathway | |||||
Integrin-mediated Cell Adhesion | |||||
References |
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