Target Information

Target General Infomation
Target ID
T57680
Former ID
TTDR00186
Target Name
Soluble guanylate cyclase
Synonyms
SGC
Target Type
Successful
Disease Angina pectoris [ICD9: 413; ICD10: I20]
BioChemical Class
Phosphorus-oxygen lyases
UniProt ID
Q02108||Q02153
EC Number
EC 4.6.1.2
Drugs and Mode of Action
Drug(s) Nitroglycerin Drug Info Approved Angina pectoris [538507], [542064]
Sodium nitroprusside Drug Info Approved Blood pressure [1559927]
Nitroglycerine Drug Info Phase 4 Discovery agent [522372]
Stimulator Endothelium-derived relaxing factor (EDRF) Drug Info [537961]
Modulator Nitroglycerin Drug Info
Sodium nitroprusside Drug Info
Activator Nitroglycerine Drug Info [535402]
YC-1 Drug Info [535402]
References
Ref 522372ClinicalTrials.gov (NCT00712894) Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction. U.S. National Institutes of Health.
Ref 538507FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018531.
Ref 542064(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7053).
Ref 1559927Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Crit Care Res Pract.2012;2012:290805.
Ref 535402Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 2002 Feb;14(1):8-14.
Ref 537961Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol. 1996 May 30;77(13):2C-7C.

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