Target Information
Target General Infomation | |||||
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Target ID |
T70792
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Former ID |
TTDNS00541
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Target Name |
Placental growth factor
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Gene Name |
PGF
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Synonyms |
PlGF; PGFL; PLGF; D12S1900; PlGF-2; SHGC-10760; PGF
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Target Type |
Successful
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Disease | Metastatic colorectal cancer [ICD9: 153, 154; ICD10: C18-C21] | ||||
Function |
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
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BioChemical Class |
PIGF family
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UniProt ID | |||||
Sequence |
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVD
VVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVEL TFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWP SSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | ||||
Metabolic pathways | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
WikiPathways | Diurnally Regulated Genes with Circadian Orthologs | ||||
synthesis of GPI-anchored proteins | |||||
References |
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