Resistance mutation info of target

Target General Information
Target ID T56915
Target Name HIV Protease Target Info
Species Human immunodeficiency virus type 1 (HIV-1)
Uniprot ID POL_HV1B1(501-599)
Sequence PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF [Human immunodeficie
ncy virus type 1 (HIV-1)]
Drug Resistance Mutation and Corresponding Drugs
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 521751ClinicalTrials.gov (NCT00246610) Safety Of VIRACEPT 625mg Administered To HIV-Infected Women During Pregnancy. U.S. National Institutes of Health.
Mutation Info Missense: D30N
Drugs
Drug Name Nelfinavir Drug Info [555734]
Targeted Disease HIV infection
Level of Resistance Confer high-level resistance to NFV
Mutation Info Missense: F53L
Drugs
Drug Name Nelfinavir Drug Info [555510], [555637], [555764]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G48A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48L
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48M
Drugs
Drug Name Nelfinavir Drug Info [555517], [555635], [555637]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Mutation Info Missense: G48Q
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: G48V
Drugs
Drug Name Nelfinavir Drug Info [555764]
Targeted Disease HIV infection
Level of Resistance Confer intermediate-level resistance to NFV
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Mutation Info Missense: G73A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G73C
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G73S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: G73T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I47A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Mutation Info Missense: I47V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: I50L
Drugs
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: I50V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556244], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54L
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54M
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I54V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: I84A
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: I84C
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: I84V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: K20T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: K65R
Drugs
Drug Name Nelfinavir Drug Info [556112]
Targeted Disease HIV infection
Mutation Prevalence 7 out of 37 samples
Mutation Info Missense: L10F
Drugs
Drug Name Nelfinavir Drug Info [555646], [555673], [555679]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV in vitro
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L23I
Drugs
Drug Name Nelfinavir Drug Info [555551]
Targeted Disease HIV infection
Level of Resistance Confer low/intermediate-level resistance to NFV
Mutation Info Missense: L24F
Drugs
Drug Name Nelfinavir Drug Info [555726], [555764]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Mutation Info Missense: L24I
Drugs
Drug Name Nelfinavir Drug Info [556195]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L33F
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: L76V
Drugs
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L89V
Drugs
Drug Name Nelfinavir Drug Info [555510], [555648], [555678]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Mutation Info Missense: L90M
Drugs
Drug Name Nelfinavir Drug Info [556184]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: L90M
Drugs
Drug Name Nelfinavir Drug Info [555965]
Targeted Disease HIV infection
Mutation Prevalence 1 out of 31 samples
Mutation Info Missense: M36I + H69K + L89M
Drugs
Drug Name Tipranavir Drug Info [555812]
Targeted Disease HIV infection
Mutation Info Missense: M41L
Drugs
Drug Name Tenofovir + Emtricitabine + Efavirenz Drug Info [556145]
Targeted Disease HIV infection
Mutation Info Missense: M46*
Drugs
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Mutation Info Missense: M46I
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: M46L
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Mutation Info Missense: M46V
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: N83D
Drugs
Drug Name Nelfinavir Drug Info [555606], [555764], [555778]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: N88D
Drugs
Drug Name Nelfinavir Drug Info [556221]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: N88G
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: N88S
Drugs
Drug Name Nelfinavir Drug Info [556221]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance High-level resistance
Mutation Info Missense: N88T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: Q58E
Drugs
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: T74P
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: T74S
Drugs
Drug Name Ritonavir Drug Info [555724]
Targeted Disease HIV infection
Mutation Info Missense: V32I
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82A
Drugs
Drug Name Nelfinavir Drug Info [555510]
Targeted Disease HIV infection
Level of Resistance Confer reduce susceptibility to NFV
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82C
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82F
Drugs
Drug Name Nelfinavir Drug Info [555764]
Targeted Disease HIV infection
Level of Resistance Reduce susceptibility to NFV
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Darunavir + Ritonavir Drug Info [556226], [556228]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82L
Drugs
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82M
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556235]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Mutation Info Missense: V82S
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Mutation Info Missense: V82T
Drugs
Drug Name Nelfinavir Drug Info [556228], [556245]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Saquinavir + Ritonavir Drug Info [556228], [556232], [556233]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Fosamprenavir + Ritonavir Drug Info [556228], [556239], [556240]
Targeted Disease HIV infection
Level of Resistance Low-level resistance
Drug Name Tipranavir + Ritonavir Drug Info [556228], [556240]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Lopinavir + Ritonavir Drug Info [556228], [556234]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Indinavir + Ritonavir Drug Info [556228], [556233]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Drug Name Atazanavir + Ritonavir Drug Info [556228], [556247]
Targeted Disease HIV infection
Level of Resistance Intermediate resistance
Reference
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Ref 556226Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe. Antivir Ther. 2004 Oct;9(5):695-702.
Ref 555551Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance. Antimicrob Agents Chemother. 2004 Dec;48(12):4864-8.
Ref 555606Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol. 2006 Nov;80(21):10794-801. Epub 2006 Aug 23.
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Ref 555646Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol. 2008 Jan;82(2):764-74. Epub 2007 Oct 31.
Ref 555648Factors associated with the selection of mutations conferring resistance to protease inhibitors (PIs) in PI-experienced patients displaying treatment failure on darunavir. Antimicrob Agents Chemother. 2008 Feb;52(2):491-6. Epub 2007 Nov 26.
Ref 555673Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res. 2008 Nov;80(2):213-22. doi: 10.1016/j.antiviral.2008.06.012. Epub 2008 Jul 14.
Ref 555678Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen. AIDS. 2008 Sep 12;22(14):1809-13. doi: 10.1097/QAD.0b013e328307f24a.
Ref 555679Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol. 2008 Nov;82(21):10366-74. doi: 10.1128/JVI.00470-08. Epub 2008 Aug 20.
Ref 555724Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage. J Antimicrob Chemother. 2009 Nov;64(5):938-44. doi: 10.1093/jac/dkp315. Epub 2009 Aug 26.
Ref 555726Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations. Antimicrob Agents Chemother. 2009 Nov;53(11):4869-78. doi: 10.1128/AAC.00592-09. Epub 2009 Aug 31.
Ref 555734Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS. 2010 Jan 2;24(1):45-53. doi: 10.1097/QAD.0b013e32832e5303.
Ref 555764HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrob Agents Chemother. 2010 Oct;54(10):4253-61. doi: 10.1128/AAC.00574-10. Epub 2010 Jul 26.
Ref 555778Improving the prediction of virological response to tipranavir: the development and validation of a tipranavir-weighted mutation score. Antivir Ther. 2010;15(7):1011-9. doi: 10.3851/IMP1670.
Ref 555812Prediction of drug-resistance in HIV-1 subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysis. Antiviral Res. 2011 Nov;92(2):213-8. doi: 10.1016/j.antiviral.2011.08.005. Epub 2011 Aug 22.
Ref 556228The HIVdb system for HIV-1 genotypic resistance interpretation. Intervirology. 2012;55(2):98-101. doi: 10.1159/000331998. Epub 2012 Jan 24.
Ref 555965HIV-1 drug-resistance surveillance among treatment-experienced and -nae patients after the implementation of antiretroviral therapy in Ghana. PLoS One. 2013 Aug 19;8(8):e71972. doi: 10.1371/journal.pone.0071972. eCollection 2013.
Ref 556232Personalized HIV therapy to control drug resistance. Drug Discov Today Technol. 2014 Mar;11:57-64. doi: 10.1016/j.ddtec.2014.02.004.
Ref 556233The emerging profile of cross-resistance among the nonnucleoside HIV-1 reverse transcriptase inhibitors. Viruses. 2014 Jul 31;6(8):2960-73. doi: 10.3390/v6082960.
Ref 556234Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors. Viruses. 2014 Sep 24;6(9):3535-62. doi: 10.3390/v6093535.
Ref 556235Current perspectives on HIV-1 antiretroviral drug resistance. Viruses. 2014 Oct 24;6(10):4095-139. doi: 10.3390/v6104095.
Ref 556239Resistance to direct-acting antiviral agents: clinical utility and significance. Curr Opin HIV AIDS. 2015 Sep;10(5):381-9. doi: 10.1097/COH.0000000000000177.
Ref 556240Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection. Future Microbiol. 2015;10(11):1773-82. doi: 10.2217/fmb.15.106. Epub 2015 Oct 30.
Ref 556112Prevalence and dynamics of the K65R drug resistance mutation in HIV-1-infected infants exposed to maternal therapy with lamivudine, zidovudine and either nevirapine or nelfinavir in breast milk. J Antimicrob Chemother. 2016 Jun;71(6):1619-26. doi: 10.1093/jac/dkw039. Epub 2016 Mar 6.
Ref 556145HIV Drug Resistance in Antiretroviral Treatment-Nae Individuals in the Largest Public Hospital in Nicaragua, 2011-2015. PLoS One. 2016 Oct 13;11(10):e0164156. doi: 10.1371/journal.pone.0164156. eCollection 2016.
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Ref 556195Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol. 1996 Dec;70(12):8270-6.
Ref 556221Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir. Antimicrob Agents Chemother. 1998 Oct;42(10):2637-44.

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