Resistance mutation info of target

Target General Information
Target ID T27445
Target Name Bacterial Isoleucyl-tRNA synthetase (ileS) Target Info
Gene Name ileS
Species Escherichia coli
Uniprot ID SYI_ECOLI
Sequence MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYA
NGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPGEKFTAA
EFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHK
GAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFQAVDQDALKAKFAVSNVNGPISLVIW
TTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAE
LELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPD
GTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQ
WFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHK
DTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGST
HSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQG
RKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTAR
FLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCS
VEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPG
EREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAV
TLYAEPELSAKLTALGDELRFVLLTSGATVADYNDAPADAQQSEVLKGLKVALSKAEGEK
CPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA [Escherichia coli]
Drug Resistance Mutation and Corresponding Drugs
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Mutation Info Missense: F227L
Drugs
Drug Name Mupirocin Drug Info [1559290]
Targeted Disease Bacterial infection
Level of Resistance Low-level resistance
Mutation Info Missense: FP187F
Drugs
Drug Name Mupirocin Drug Info [1559290]
Targeted Disease Bacterial infection
Level of Resistance Low-level resistance
Mutation Info Missense: K226T
Drugs
Drug Name Mupirocin Drug Info [1559290]
Targeted Disease Bacterial infection
Level of Resistance Low-level resistance
Mutation Info Missense: Q612H
Drugs
Drug Name Mupirocin Drug Info [1559290]
Targeted Disease Bacterial infection
Level of Resistance Low-level resistance
Mutation Info Missense: V588
Drugs
Drug Name Mupirocin Drug Info [1559290]
Targeted Disease Bacterial infection
Level of Resistance Low-level resistance
Mutation Info Missense: V767D
Drugs
Drug Name Mupirocin Drug Info [1559290]
Targeted Disease Bacterial infection
Level of Resistance Low-level resistance
Reference
Ref 1559290Molecular analysis of isoleucyl-tRNA synthetase mutations in clinical isolates of methicillin-resistant Staphylococcus aureus with low-level mupirocin resistance.

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