Resistance mutation info of target

Target General Information
Target ID T05152
Target Name HCV RNA-directed RNA polymerase (NS5B) Target Info
Gene Name NS5B
Species Hepatitis C virus genotype 1b
Uniprot ID POLG_HCVJA(2420-3010)
Sequence SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIY
QCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR [Hepatit
is C virus genotype 1b]
Drug Resistance Mutation and Corresponding Drugs
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 538312FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076192.
Ref 541922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6842).
Mutation Info Missense: F415Y
Drugs
Drug Name Ribavirin Drug Info [555691]
Targeted Disease HCV infection
Mutation Info Missense: S282T
Drugs
Drug Name Sofosbuvir Drug Info [556265]
Targeted Disease HCV infection
Level of Resistance Confer 9.5 fold resistance
Reference
Ref 555691Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-nae patients. Hepatology. 2008 Dec;48(6):1769-78. doi: 10.1002/hep.22549.
Ref 556265Lam, A.M. et al. Selection and characterization of heaptitis C virus replicons using combinations of NS3 protease and NS5B non-nucleoside inhibitors or combination of NS5B nucleotide inhibitors. . in International HIV & Hepatitis Virus Drug Resistance Workshop, Vol. 15 Supplement 2 A28 (Dubrovnik, Croatia, 2010).

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