Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| DHFR --- TYMS | 2-Amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | N-[4-[(2,4-Diamino-5-propyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl]-L-glutamic Acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one | Drug Info |
| DHFR --- TYMS | 2-Amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo-[2,3-d]pyrimidin-5-yl)thio]-2'fluorobenzoyl]L-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-{4-[(4-Hydroxy-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 4-{4-[4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-4-carboxy-butyrylamino}-4-carboxy-butyric acid anion | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 4-(4-{4-[4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-4-carboxy-butyrylamino}-4-carboxy-butyrylamino)-4-carboxy-butyric acid anion | Drug Info |
| DHFR --- TYMS | N-{4-[(2-Amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl}-L-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | N-{4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl}-L-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-5-oxo-pentanoic acid anion | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-cyanomethyl-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | CHEMBL422395 | Drug Info |
| DHFR --- TYMS | 2-Amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | Drug Info |
| DHFR --- TYMS | 2-Amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | (S)-2-{4-[2-(2-Amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-(4-{[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-methyl-amino]-methyl}-benzoylamino)-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 4-[4-(4-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-4-carboxy-butyric acid anion | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid | Drug Info |
| DHFR --- TYMS | [3H]-Pemetrexed | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyric acid anion | Drug Info |
| DHFR --- TYMS | 2-[4-(2-Amino-6-methyl-4-oxo-4,4a,7,7a-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylsulfanyl)-benzoylamino]-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 3,3-bis-(3,5-dibromo-4-hydroxy-phenyl)-3H-benzo[de]isochromen-1-one | Drug Info |
| DHFR --- TYMS | N-{4-[(2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio]benzoyl}-L-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | (2S)-2-(5-{[(2-Amino-4-oxo-3,4-dihydro[1]benzothieno-[2,3-d]pyrimidin-5-yl)methyl]amino}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid | Drug Info |
| DHFR --- TYMS | N-[4-[(2-amino-6-ethyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]-pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | SID536361 | Drug Info |
| DHFR --- TYMS | CHEMBL3303081 | Drug Info |
| DHFR --- TYMS | N-{4-[(2-amino-6-methyl-4-oxo-3,4-dihydro-5 H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]benzoyl}-l-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | N-[4-[(2,4-Diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | Drug Info |
| DHFR --- TYMS | N-(4-{[(2-Amino-4-oxo-3,4-dihydro[1]benzothieno[2,3-d]pyrimidin-5-yl)methyl]amino}benzoyl)-L-glutamic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
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