Drug Information

Drug General Information
Drug ID
DXY8NI
Drug Name
4-[(4-Chlorophenyl)methyl]-2-[(1-methyl-3-pyrrolidinyl)methyl]-1(2H)-phthalazinone
Synonyms
CHEMBL1767155
Indication Discovery agent Investigative [1587926]
Formula
C21H22ClN3O
Canonical SMILES
CN1CCC(CN2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O)C1
InChI
InChI=1S/C21H22ClN3O/c1-24-11-10-16(13-24)14-25-21(26)19-5-3-2-4-18(19)20(23-25)12-15-6-8-17(22)9-7-15/h2-9,16H,10-14H2,1H3
InChIKey
OIZYYUJMNZAXNN-UHFFFAOYSA-N
Target and Pathway
Target(s) Alpha-1 adrenergic receptor Target Info [1587926]
Histamine H1 receptor Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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