Drug Information

Drug General Information
Drug ID
DXY20Z
Drug Name
2-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-yl]-3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane
Synonyms
CHEMBL607052
Indication Discovery agent Investigative [1587926]
Formula
C22H21BrClN3O
Canonical SMILES
CN1[C@@H]2CCC1C([C@H](C2)c3ccc(Cl)cc3)c4onc(n4)c5ccc(Br)cc5
InChI
InChI=1S/C22H21BrClN3O/c1-27-17-10-11-19(27)20(18(12-17)13-4-8-16(24)9-5-13)22-25-21(26-28-22)14-2-6-15(23)7-3-14/h2-9,17-20H,10-12H2,1H3/t17-,18-,19?,20?/m1/s1
InChIKey
FVBNPVXVBDJFEC-UVHRUJRTSA-N
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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