Drug Information

Drug General Information
Drug ID
DXX4MA
Drug Name
2-(2-Phenyl-1H-benzoimidazole-5-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL344827
Indication Discovery agent Investigative [1587926]
Formula
C23H20N4O4S
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc4[nH]c(nc4c3)c5ccccc5
InChI
InChI=1S/C23H20N4O4S/c28-23(26-29)21-12-16-8-4-5-9-17(16)14-27(21)32(30,31)18-10-11-19-20(13-18)25-22(24-19)15-6-2-1-3-7-15/h1-11,13,21,29H,12,14H2,(H,24,25)(H,26,28)
InChIKey
HXTKAAOSFRMCEF-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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