Drug Information

Drug General Information
Drug ID
DXX4LM
Drug Name
4-[(4-Chlorophenyl)methyl]-2-[3-(dimethylamino)propyl]-1(2H)-phthalazinone
Synonyms
CHEMBL1767135
Indication Discovery agent Investigative [1587926]
Formula
C20H22ClN3O
Canonical SMILES
CN(C)CCCN1N=C(Cc2ccc(Cl)cc2)c3ccccc3C1=O
InChI
InChI=1S/C20H22ClN3O/c1-23(2)12-5-13-24-20(25)18-7-4-3-6-17(18)19(22-24)14-15-8-10-16(21)11-9-15/h3-4,6-11H,5,12-14H2,1-2H3
InChIKey
SAKVKDBLCRHLAV-UHFFFAOYSA-N
Target and Pathway
Target(s) Alpha-1 adrenergic receptor Target Info [1587926]
Histamine H1 receptor Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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