Drug Information

Drug General Information
Drug ID
DXW5NS
Drug Name
(R)-N-hydroxy-3-methyl-2-(N-(2-morpholinoethyl)naphthalene-2-sulfonamido)butanamide
Synonyms
CHEMBL1916652
Indication Discovery agent Investigative [1587926]
Formula
C21H29N3O5S
Canonical SMILES
CC(C)[C@@H](N(CCN1CCOCC1)S(=O)(=O)c2ccc3ccccc3c2)C(=O)NO
InChI
InChI=1S/C21H29N3O5S/c1-16(2)20(21(25)22-26)24(10-9-23-11-13-29-14-12-23)30(27,28)19-8-7-17-5-3-4-6-18(17)15-19/h3-8,15-16,20,26H,9-14H2,1-2H3,(H,22,25)/t20-/m1/s1
InChIKey
WHSJFJHSWYAKDM-HXUWFJFHSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Collagenase 3 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP474:Endochondral Ossification
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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