Drug Information

Drug General Information
Drug ID
DXT6FB
Drug Name
N3-(2-chlorophenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine
Synonyms
CHEMBL1835742
Indication Discovery agent Investigative [1587926]
Formula
C13H11ClN6
Canonical SMILES
Nc1nc(Nc2ccccc2Cl)nn1c3ccccn3
InChI
InChI=1S/C13H11ClN6/c14-9-5-1-2-6-10(9)17-13-18-12(15)20(19-13)11-7-3-4-8-16-11/h1-8H,(H3,15,17,18,19)
InChIKey
KIUVCQMGYRAZME-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
FL cytokine receptor Target Info [1587926]
KEGG Pathway Oocyte meiosishsa04060:Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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