Drug Information

Drug General Information
Drug ID
DXP8R3
Drug Name
CHEMBL518981
Indication Discovery agent Investigative [1587926]
Formula
C27H30N6O4S
Canonical SMILES
COc1cc2c(Nc3ncc(CC(=O)Nc4ccccc4)s3)ncnc2cc1OCCCN5CCOCC5
InChI
InChI=1S/C27H30N6O4S/c1-35-23-15-21-22(16-24(23)37-11-5-8-33-9-12-36-13-10-33)29-18-30-26(21)32-27-28-17-20(38-27)14-25(34)31-19-6-3-2-4-7-19/h2-4,6-7,15-18H,5,8-14H2,1H3,(H,31,34)(H,28,29,30,32)
InChIKey
JMKSPIHWHMYVFU-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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