Drug Information
| Drug General Information | |||||
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| Drug ID |
DXP3GF
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| Drug Name |
(2E)-N-[4-({4-[(3,4-difluorobenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
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| Synonyms |
CHEMBL243628
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H27F2N5O5
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OCc4ccc(F)c(F)c4)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C29H27F2N5O5/c1-4-40-26-13-21-18(11-23(26)34-28(39)6-5-9-36(2)3)29(33-16-32-21)35-22-12-25(38)27(14-24(22)37)41-15-17-7-8-19(30)20(31)10-17/h5-8,10-14,16H,4,9,15H2,1-3H3,(H,34,39)(H,32,33,35)/b6-5+
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| InChIKey |
CCIOQSAJAUYKQV-AATRIKPKSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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