Drug Information

Drug General Information
Drug ID
DXM3NZ
Drug Name
5-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-5-oxo-pentanoic acid
Synonyms
CHEMBL378816
Indication Discovery agent Investigative [1587926]
Formula
C30H31BrClN5O4
Canonical SMILES
OC(=O)CCCC(=O)N1CCN(CC1C(=O)NCc2cccnc2)C3c4ccc(Cl)cc4CCc5cc(Br)cnc35
InChI
InChI=1S/C30H31BrClN5O4/c31-22-13-21-7-6-20-14-23(32)8-9-24(20)29(28(21)34-17-22)36-11-12-37(26(38)4-1-5-27(39)40)25(18-36)30(41)35-16-19-3-2-10-33-15-19/h2-3,8-10,13-15,17,25,29H,1,4-7,11-12,16,18H2,(H,35,41)(H,39,40)
InChIKey
GXROPRYKIVOUEO-UHFFFAOYSA-N
Target and Pathway
Target(s) Farnesyltransferase Target Info [1587926]
Protein farnesyltransferase beta subunit Target Info [1587926]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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