Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXHB7P
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| Drug Name |
(2E)-N-{4-[(4-bromo-2-fluorophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
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| Synonyms |
CHEMBL242131
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C20H19BrFN5O
|
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| Canonical SMILES |
CN(C)C\\C=C\\C(=O)Nc1ccc2ncnc(Nc3ccc(Br)cc3F)c2c1
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| InChI |
InChI=1S/C20H19BrFN5O/c1-27(2)9-3-4-19(28)25-14-6-8-17-15(11-14)20(24-12-23-17)26-18-7-5-13(21)10-16(18)22/h3-8,10-12H,9H2,1-2H3,(H,25,28)(H,23,24,26)/b4-3+
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| InChIKey |
SLZOGARBQLIHCR-ONEGZZNKSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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