Drug Information

Drug General Information
Drug ID
DXH3DH
Drug Name
7-((S)-2-Amino-propionylamino)-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL140863
Indication Discovery agent Investigative [1587926]
Formula
C20H24N4O6S
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N2Cc3cc(NC(=O)[C@H](C)N)ccc3CC2C(=O)NO
InChI
InChI=1S/C20H24N4O6S/c1-12(21)19(25)22-15-4-3-13-10-18(20(26)23-27)24(11-14(13)9-15)31(28,29)17-7-5-16(30-2)6-8-17/h3-9,12,18,27H,10-11,21H2,1-2H3,(H,22,25)(H,23,26)/t12-,18?/m0/s1
InChIKey
MKTUSESWUSYVIL-RSXQAXDFSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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