Drug Information

Drug General Information
Drug ID
DXGZ9E
Drug Name
2-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophene-2-sulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL141340
Indication Discovery agent Investigative [1587926]
Formula
C19H18N4O4S3
Canonical SMILES
CSc1nccc(n1)c2ccc(s2)S(=O)(=O)N3Cc4ccccc4CC3C(=O)NO
InChI
InChI=1S/C19H18N4O4S3/c1-28-19-20-9-8-14(21-19)16-6-7-17(29-16)30(26,27)23-11-13-5-3-2-4-12(13)10-15(23)18(24)22-25/h2-9,15,25H,10-11H2,1H3,(H,22,24)
InChIKey
WYWULSIANADMTA-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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