Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXG8XO
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| Drug Name |
methyl N-(5-(4-((2-fluoro-5-aminophenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate
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| Synonyms |
CHEMBL396284
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C22H19FN6O4
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| Canonical SMILES |
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(N)ccc4F)cc3)cc2[nH]1
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| InChI |
InChI=1S/C22H19FN6O4/c1-32-22(31)29-20-26-17-9-7-15(11-19(17)27-20)33-14-5-3-13(4-6-14)25-21(30)28-18-10-12(24)2-8-16(18)23/h2-11H,24H2,1H3,(H2,25,28,30)(H2,26,27,29,31)
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| InChIKey |
KOBWXOJJEJSUST-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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