Drug Information

Drug General Information
Drug ID
DXFT7J
Drug Name
(S)-N-[3-Hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-3-phenylacetylamino-succinamic acid tert-butyl ester
Synonyms
CHEMBL141004
Indication Discovery agent Investigative [1587926]
Formula
C33H38N4O9S
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N2Cc3cc(NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)Cc4ccccc4)ccc3CC2C(=O)NO
InChI
InChI=1S/C33H38N4O9S/c1-33(2,3)46-30(39)19-27(35-29(38)16-21-8-6-5-7-9-21)31(40)34-24-11-10-22-18-28(32(41)36-42)37(20-23(22)17-24)47(43,44)26-14-12-25(45-4)13-15-26/h5-15,17,27-28,42H,16,18-20H2,1-4H3,(H,34,40)(H,35,38)(H,36,41)/t27-,28?/m0/s1
InChIKey
UKBWLBZDMUKXSY-MBMZGMDYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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