Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXF9N2
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| Drug Name |
(3R,5S)-5-((4-(3-chloro-4-(5-methylisoxazol-3-yloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL461811
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C27H25ClN6O5S
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| Canonical SMILES |
Cc1onc(Oc2ccc(Nc3ncnc4cc(C#C[C@@H]5C[C@H](CN5)OC(=O)N6CCOCC6)sc34)cc2Cl)c1
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| InChI |
InChI=1S/C27H25ClN6O5S/c1-16-10-24(33-39-16)38-23-5-3-18(12-21(23)28)32-26-25-22(30-15-31-26)13-20(40-25)4-2-17-11-19(14-29-17)37-27(35)34-6-8-36-9-7-34/h3,5,10,12-13,15,17,19,29H,6-9,11,14H2,1H3,(H,30,31,32)/t17-,19-/m1/s1
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| InChIKey |
SBYLTLVZZWSDEP-IEBWSBKVSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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