Drug Information

Drug General Information
Drug ID
DXB0KN
Drug Name
3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(4-methylbenzoyl)piperidine-3-carboxamide
Synonyms
CHEMBL399098
Indication Discovery agent Investigative [1587926]
Formula
C25H28N2O6S
Canonical SMILES
CC#CCOc1ccc(cc1)S(=O)(=O)CC2(CCCN(C2)C(=O)c3ccc(C)cc3)C(=O)NO
InChI
InChI=1S/C25H28N2O6S/c1-3-4-16-33-21-10-12-22(13-11-21)34(31,32)18-25(24(29)26-30)14-5-15-27(17-25)23(28)20-8-6-19(2)7-9-20/h6-13,30H,5,14-18H2,1-2H3,(H,26,29)
InChIKey
LEMMSOIQHPOJRA-UHFFFAOYSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Collagenase 3 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP474:Endochondral Ossification
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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