Drug Information

Drug General Information
Drug ID
DX8SAS
Drug Name
{2-[4-(4-Dimethylamino-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid
Synonyms
CHEMBL337761
Indication Discovery agent Investigative [1587926]
Formula
C25H24N2O6S
Canonical SMILES
CN(C)c1ccc(Oc2ccc(cc2)S(=O)(=O)N3Cc4ccccc4CC3C(=O)C(=O)O)cc1
InChI
InChI=1S/C25H24N2O6S/c1-26(2)19-7-9-20(10-8-19)33-21-11-13-22(14-12-21)34(31,32)27-16-18-6-4-3-5-17(18)15-23(27)24(28)25(29)30/h3-14,23H,15-16H2,1-2H3,(H,29,30)
InChIKey
XIMLFZSNGXTRSL-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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