Drug Information

Drug General Information
Drug ID
DX8FWG
Drug Name
(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-5-ethyl-N-phenyl-2-morpholinecarboxamide
Synonyms
CHEMBL1765742
Indication Discovery agent Investigative [1587926]
Formula
C25H28N8O2
Canonical SMILES
CC[C@@H]1CO[C@@H](CN1c2cc(nc(NC)n2)c3ccc4c(N)n[nH]c4c3)C(=O)Nc5ccccc5
InChI
InChI=1S/C25H28N8O2/c1-3-17-14-35-21(24(34)28-16-7-5-4-6-8-16)13-33(17)22-12-19(29-25(27-2)30-22)15-9-10-18-20(11-15)31-32-23(18)26/h4-12,17,21H,3,13-14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t17-,21+/m1/s1
InChIKey
QLCDVXBLLOIZEO-UTKZUKDTSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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