Drug Information

Drug General Information
Drug ID
DX7PON
Drug Name
N-(3-{4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)acetamide
Synonyms
CHEMBL1099343
Indication Discovery agent Investigative [1587926]
Formula
C33H29N7O2
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(cc23)c4cccc(NC(=O)C)c4)c(n1)c5ccc(NC(=O)Nc6ccccc6)cc5
InChI
InChI=1S/C33H29N7O2/c1-3-40-20-29(31(39-40)22-12-14-25(15-13-22)37-33(42)36-24-9-5-4-6-10-24)27-16-17-34-32-28(27)19-30(38-32)23-8-7-11-26(18-23)35-21(2)41/h4-20H,3H2,1-2H3,(H,34,38)(H,35,41)(H2,36,37,42)
InChIKey
CSFNNUIZTRGKSQ-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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