Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX7KBU
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| Drug Name |
2-(2-(4-methyl-1-piperazino)ethylamino)-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1Hbenzimidazole
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| Synonyms |
CHEMBL390696
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C28H29F4N7O2
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| Canonical SMILES |
CN1CCN(CCNc2nc3ccc(Oc4ccc(NC(=O)Nc5cc(ccc5F)C(F)(F)F)cc4)cc3[nH]2)CC1
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| InChI |
InChI=1S/C28H29F4N7O2/c1-38-12-14-39(15-13-38)11-10-33-26-35-23-9-7-21(17-25(23)36-26)41-20-5-3-19(4-6-20)34-27(40)37-24-16-18(28(30,31)32)2-8-22(24)29/h2-9,16-17H,10-15H2,1H3,(H2,33,35,36)(H2,34,37,40)
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| InChIKey |
UPGBUHOFLSJEEI-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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